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A review of nicotinamide: treatment of skin diseases and potential side effects
Author(s) -
Rolfe Heidi M
Publication year - 2014
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12119
Subject(s) - nicotinamide , niacinamide , niacin , medicine , dermatology , psoriasis , rosacea , pellagra , acne , atopic dermatitis , pharmacology , skin cancer , chemistry , biochemistry , cancer , enzyme
Summary Nicotinamide, also known as niacinamide, is the amide form of vitamin B3. It is a precursor of essential coenzymes for numerous reactions in the body including adenosine triphosphate ( ATP ) production. Nicotinic acid, also known as niacin, is converted into nicotinamide in the body. The use of topical nicotinamide in the treatment of acne vulgaris; melasma; atopic dermatitis; rosacea; and oral nicotinamide in preventing nonmelanoma skin cancer is discussed. The possible side effects and consequences of excessive nicotinamide exposure are reviewed, including suggestions nicotinamide might have a role in the development of diabetes, Parkinson's disease, and liver damage.