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Dyspigmentation, skin physiology, and a novel approach to skin lightening
Author(s) -
Draelos Zoe,
Dahl Amanda,
Yatskayer Margarita,
Chen Nannan,
Krol Yevgeniy,
Oresajo Christian
Publication year - 2013
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12066
Subject(s) - tolerability , ellagic acid , medicine , kojic acid , dermatology , tretinoin , salicylic acid , pharmacology , chemistry , polyphenol , retinoic acid , tyrosinase , biochemistry , adverse effect , antioxidant , enzyme , gene
Summary Background Even facial pigmentation is considered a universal sign of youth and beauty in all cultures and at all ages in both men and women. The recent FDA concern about the safety of topical hydroquinone has provided the impetus for research into new pigment lightening alternatives in the cosmetic OTC market. Aim This research examined a novel hydroxyphenoxy propionic acid, ellagic acid, yeast extract, and salicylic acid formulation applied twice daily compared to the standard prescription combination of 4% hydroquinone cream and 0.025% tretinoin cream applied nightly. Method This single‐center investigator‐blinded 12 week study enrolled 82 subjects (7 male, 75 female) ages 25–60 years divided into 2 balanced groups of 41 subjects each with one group using a novel hydroxyphenoxy propionic acid, ellagic acid, yeast extract, and salicylic acid formulation applied twice daily compared to the standard prescription combination of 4% hydroquinone cream and 0.025% tretinoin cream applied nightly. Results Significant tolerability issues arose with the prescription combinations that were not seen with the cosmetic formulation. In terms of ability to even skin tone, decrease spot intensity, decrease spot size, and improve overall pigmentation, both products demonstrated parity. Conclusion This research demonstrated the value of cosmetic formulations as part of a treatment regimen for pigmentation issues.