Premium
Neodymium‐yttrium aluminum garnet laser versus pulsed dye laser in erythemato‐telangiectatic rosacea: comparison of clinical efficacy and effect on cutaneous substance ( P ) expression
Author(s) -
Salem Samar Abdallah M,
Abdel Fattah Nermeen SA,
Tantawy Samah MA,
ElBadawy Nafissa MA,
Abd ElAziz Yasser A
Publication year - 2013
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12048
Subject(s) - rosacea , telangiectasia , erythema , medicine , laser , dermatology , nd:yag laser , optics , acne , physics
Summary Background Different laser systems are reported to be effective in treatment of telangiectasia and erythema, but comparative studies on 1064‐nm neodymium‐yttrium aluminum garnet ( N d‐ YAG ) laser and pulsed dye laser ( PDL ) in treatment of erythemato‐telangiectatic rosacea are lacking. Substance ( P ) is implicated in rosacea pathogenesis. Objectives To compare the effect of N d‐ YAG laser and PDL on erythemato‐telangiectatic rosacea, both clinically and immunohistochemically on cutaneous substance ( P ) expression. Methods This split‐face comparative study included 15 patients with erythemato‐telangiectatic rosacea treated on the right side with N d‐ YAG laser and on the left side with PDL : three sessions, 4 weeks apart. Evaluation of the patients was done using erythema and telangiectasia grading scores, patient's self‐assessment, physicians' clinical assessment of the patient, and immunohistochemical assessment of substance ( P ). Results One month after the three laser sessions, excellent response was achieved in 73.3% of patients after N d‐ YAG and in 53.3% of patients after PDL with significantly lower substance ( P ) concentration after N d‐ YAG laser than after PDL . Positive correlations were found between the decrease in erythema and telangiectasia grading scores and the decrease in substance ( P ) concentration. Conclusions The use of N d‐ YAG laser and PDL appears to be safe and effective measures in treatment of erythemato‐telangiectatic rosacea. Both types of laser decrease the concentration of substance ( P ) in the skin. This effect is more pronounced with N d‐ YAG laser.