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Intense pulsed light enhances transforming growth factor beta1/ S mad3 signaling in acne‐prone skin
Author(s) -
Ali Musheera M,
Porter Rebecca M,
Gonzalez Maria L
Publication year - 2013
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12045
Subject(s) - intense pulsed light , acne , epidermis (zoology) , dermis , immunohistochemistry , transforming growth factor , medicine , chemistry , pathology , dermatology , anatomy
Summary Background Recently, much interest has been generated in the use of intense pulsed light ( IPL ) sources in the treatment of various skin conditions. However, the underlying mechanism for its therapeutic action has not been elucidated. Objective To investigate the effect of IPL on the in vivo expression of transforming growth factor beta1 ( TGF ‐β1) and on the immunolocalization of S mad3 in biopsies obtained from perilesional skin in patients with mild‐to‐moderate inflammatory acne vulgaris. Methods Biopsies obtained from 20 patients with inflammatory acne vulgaris at baseline ( B 1) and post‐ IPL treatment ( B 2 = 48 h after first treatment and B 3 = 1 week after final treatment) were immunohistochemically analyzed to determine the expression of TGF ‐β1 and the immunolocalization of S mad3. Digital images were semiquantitatively assessed using image analysis software. Results Intense pulsed light elicited a consistent increase in epidermal TGF ‐β1 expression ( B 2 vs . B 1: P = 0.004 and B 3 vs . B 1: P = 0.007). Furthermore, it resulted in enhanced nuclear immunolocalization of S mad3 ( B 2 vs . B 1: epidermis, P = 0.000055 and dermis, P = 0.014; B 3 vs . B 1: epidermis, P = 0.00024 and dermis, P = 0.008). Conclusion Intense pulsed light upregulates TGF ‐β1/ S mad3 signaling in perilesional skin obtained from patients with mild‐to‐moderate inflammatory acne vulgaris. Further experiments on lesional skin and downstream effects are warranted to determine whether it may play a role in IPL ‐induced resolution of acne vulgaris.