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SIG 1273: a new cosmetic functional ingredient to reduce blemishes and P ropionibacterium acnes in acne prone skin
Author(s) -
Fernandéz José R,
Rouzard Karl,
Voronkov Michael,
Feng Xuyan,
Stock Jeffry B,
Stock Maxwell,
Gordon Joel S,
Shroot Braham,
Christensen Michael S,
Pérez Eduardo
Publication year - 2012
Publication title -
journal of cosmetic dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.626
H-Index - 44
eISSN - 1473-2165
pISSN - 1473-2130
DOI - 10.1111/jocd.12002
Subject(s) - acne , propionibacterium acnes , ingredient , medicine , dermatology , pathology
Summary Background P ropionibacterium acnes is a major contributing factor to the inflammatory component of acne. The interaction of P . acnes with keratinocytes leads to an innate immune response via activation of toll‐like receptors ( TLR 2, TLR 4) resulting in the production and secretion of pro‐inflammatory mediators. SIG 1273, an isoprenylcysteine small molecule modulates inflammatory signaling pathways and kills P . acnes . SIG 1273 represents a novel cosmetic functional ingredient that provides relief from blemishes in acne prone skin. Objective To assess the keratinocyte response and microbial growth of SIG 1273 in vitro and evaluate the tolerability of SIG 1273 gel applied topically in acne prone subjects. Methods For in vitro studies, human keratinocytes were exposed in culture to live P . acnes and peptidoglycan ( PGN ) to induce IL ‐8 production. P . acnes were cultured to determine minimal inhibitory concentration and minimal bactericidal concentration values. A total of 30 subjects were randomized in a double‐blind controlled trial receiving 3% SIG 1273 gel or vehicle for 6 weeks. Evaluation included inflammatory lesions, noninflammatory lesions, microcomedones, S ebutape scores, and P . acnes counts. Results In vitro studies demonstrate SIG 1273 inhibits P . acnes ‐induced IL ‐8 production and inhibits P . acnes growth. SIG 1273 gel was well tolerated with no signs of stinging, redness, or itching. Furthermore, improvement in some aspects of acne was observed in subjects applying SIG 1273 gel, including inflammatory lesions, microcomedone counts and S ebutape scores. Facial scrubs taken to measure P . acnes colony‐forming units showed those applying SIG 1273 gel had ~1.0 L og 10 colony reduction over the length of the study, a statistically significantly improvement when compared with vehicle. No significant effects above vehicle were observed for noninflammatory lesions. Conclusions SIG 1273 represents a novel cosmetic functional ingredient that provides a safe dual modulating benefit to individuals with acne prone skin by reducing P . acnes counts and reducing inflammation.