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Major urinary protein excreted in rodent hindpaw sweat
Author(s) -
Poitras Trevor,
Piragasam Ramanaguru Siva,
Joy Twinkle,
Jackson Jesse,
Chandrasekhar Ambika,
Fahlman Richard,
Zochodne Douglas W.
Publication year - 2021
Publication title -
journal of anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 118
eISSN - 1469-7580
pISSN - 0021-8782
DOI - 10.1111/joa.13423
Subject(s) - sweat , lipocalin , rodent , sniffing , biology , sweat gland , thermoregulation , urinary system , endocrinology , medicine , neuroscience , ecology
Alternative roles for sweat production beyond thermoregulation, considered less frequently, include chemical signaling. We identified the presence of a well‐established rodent urinary pheromone, major urinary protein (MUP) in sweat ductules of the footpad dermal skin of mice. A hindpaw sweat proteomic analysis in hindpaw sweat samples collected in rats and generated by unmyelinated axon activation, identified seven lipocalin family members including MUP and 19 additional unique proteins. Behavioural responses to sniffing male mouse foot protein lysates suggested avoidance in a subset of male mice, but were not definitive. Rodent hindpaw sweat glands secrete a repertoire of proteins that include MUPs known to have roles in olfactory communication.