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Fsp1 cardiac embryonic expression delineates atrioventricular endocardial cushion, coronary venous and lymphatic valve development
Author(s) -
CanoBallesteros Sara,
PalmquistGomes Paul,
MarínSedeño Ernesto,
Guadix Juan Antonio,
PérezPomares José María
Publication year - 2021
Publication title -
journal of anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 118
eISSN - 1469-7580
pISSN - 0021-8782
DOI - 10.1111/joa.13306
Subject(s) - endocardium , lymphatic system , atrioventricular valve , atrioventricular cushions , venous valves , morphogenesis , cardiac valve , mesoderm , microbiology and biotechnology , biology , anatomy , medicine , embryonic stem cell , pathology , vein , heart disease , gene , ventricle , biochemistry
Fsp1 (a.k.a S100A4 or Metastatin) is an intracellular and secreted protein widely regarded as a fibroblast marker. Recent studies have nonetheless shown that Fsp1 is also expressed by other cell types, including small subsets of endothelial cells. Since no detailed and systematic description of Fsp1 spatio‐temporal expression pattern in cardiac vascular cells is available in the literature, we have used a transgenic murine line (Fsp1‐GFP) to study Fsp1 expression in the developing and postnatal cardiac vasculature and endocardium. Our work shows that Fsp1 is expressed in the endocardium and mesenchyme of atrioventricular valve primordia, as well as in some coronary venous and lymphatic endothelial cells. Fsp1 expression in cardiac venous and lymphatic endothelium is progressively restricted to the leaflets of cardiac venous and lymphatic valves. Our results suggest that Fsp1 could play a role in the development of atrioventricular valves and participate in the patterning and morphogenesis of cardiac venous and lymphatic vessel valves.