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Widening control of fin inter‐rays in zebrafish and inferences about actinopterygian fins
Author(s) -
Murciano Carmen,
CazorlaVázquez Salvador,
Gutiérrez Javier,
Hijano Juan Antonio,
RuizSánchez Josefa,
MesaAlmagro Laura,
MartínReyes Flores,
Fernández Tahía Diana,
MaríBeffa Manuel
Publication year - 2018
Publication title -
journal of anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 118
eISSN - 1469-7580
pISSN - 0021-8782
DOI - 10.1111/joa.12785
Subject(s) - zebrafish , biology , fish fin , fin , hedgehog , developmental biology , sonic hedgehog , anatomy , appendage , morpholino , microbiology and biotechnology , neuroscience , cell fate determination , regeneration (biology) , signal transduction , gene , fish <actinopterygii> , genetics , transcription factor , fishery , materials science , composite material
The amputation of a teleost fin rapidly triggers an intricate maze of hierarchically regulated signalling processes which ultimately reconstruct the diverse tissues of the appendage. Whereas the generation of the fin pattern along the proximodistal axis brings with it several well‐known developmental regulators, the mechanisms by which the fin widens along its dorsoventral axis remain poorly understood. Utilizing the zebrafish as an experimental model of fin regeneration and studying more than 1000 actinopterygian species, we hypothesized a connection between specific inter‐ray regulatory mechanisms and the morphological variability of inter‐ray membranes found in nature. To tackle these issues, both cellular and molecular approaches have been adopted and our results suggest the existence of two distinguishable inter‐ray areas in the zebrafish caudal fin, a marginal and a central region. The present work associates the activity of the cell membrane potassium channel kcnk5b , the fibroblast growth factor receptor 1 and the sonic hedgehog pathway to the control of several cell functions involved in inter‐ray wound healing or dorsoventral regeneration of the zebrafish caudal fin. This ray‐dependent regulation controls cell migration, cell‐type patterning and gene expression. The possibility that modifications of these mechanisms are responsible for phenotypic variations found in euteleostean species, is discussed.