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Induction of phosphorylated c‐Jun in neonatal spinal motoneurons after axonal injury is coincident with both motoneuron death and regeneration
Author(s) -
Yuan Qiuju,
Su Huanxing,
Guo Jiasong,
Wu Wutian,
Lin ZhiXiu
Publication year - 2014
Publication title -
journal of anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 118
eISSN - 1469-7580
pISSN - 0021-8782
DOI - 10.1111/joa.12165
Subject(s) - regeneration (biology) , c jun , crush injury , degeneration (medical) , biology , neuroscience , axonal degeneration , medicine , phosphorylation , anatomy , microbiology and biotechnology , pathology , surgery , gene , transcription factor , biochemistry
c‐Jun activation has been implicated not only in neuronal degeneration, but also in survival and regeneration. Here, we investigated c‐Jun activation in injured motoneurons by using a nerve crush model in neonatal rats. We identified two distinct subpopulations of motoneurons: about 60% underwent degeneration following injury whereas the remaining 40% survived and induced a regeneration response at 3 weeks post injury. However, all motoneurons examined expressed phosphorylated‐c‐Jun‐immunoreactivity (p‐c‐Jun‐ IR ) at the early stage of 3 days following injury. These results suggest that active c‐Jun was induced in all neonatal motoneurons following nerve crush injury, regardless of whether they were destined to degenerate or undergo successful regeneration at a later stage. Our findings therefore support the hypothesis that active c‐Jun is involved in both neuronal degeneration and regeneration.