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Protein kinase C isoforms at the neuromuscular junction: localization and specific roles in neurotransmission and development
Author(s) -
Lanuza Maria A.,
Santafe Manel M.,
Garcia Neus,
Besalduch Núria,
Tomàs Marta,
Obis Teresa,
Priego Mercedes,
Nelson Phillip G.,
Tomàs Josep
Publication year - 2014
Publication title -
journal of anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 118
eISSN - 1469-7580
pISSN - 0021-8782
DOI - 10.1111/joa.12106
Subject(s) - neuromuscular junction , protein kinase c , neurotransmission , gene isoform , phosphorylation , microbiology and biotechnology , synapse , neurotransmitter , biology , kinase , neuroscience , protein kinase a , biochemistry , receptor , gene , central nervous system
The protein kinase C family ( PKC ) regulates a variety of neural functions including neurotransmitter release. The selective activation of a wide range of PKC isoforms in different cells and domains is likely to contribute to the functional diversity of PKC phosphorylating activity. In this review, we describe the isoform localization, phosphorylation function, regulation and signalling of the PKC family at the neuromuscular junction. Data show the involvement of the PKC family in several important functions at the neuromuscular junction and in particular in the maturation of the synapse and the modulation of neurotransmission in the adult.