Premium
Genetics of Guillain‐Barré syndrome ( GBS ) and chronic inflammatory demyelinating polyradiculoneuropathy ( CIDP ): current knowledge and future directions
Author(s) -
Blum Stefan,
McCombe Pamela A.
Publication year - 2014
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/jns5.12074
Subject(s) - polyradiculoneuropathy , guillain barre syndrome , human leukocyte antigen , immunology , medicine , disease , gene , immune system , genetic predisposition , multiple sclerosis , antigen , genetics , biology
Guillain‐Barré syndrome ( GBS ) and chronic inflammatory demyelinating polyradiculoneuropathy ( CIDP ) are thought to be autoimmune diseases. There have been many attempts to find a human leukocyte antigen ( HLA ) association with GBS and CIDP with little success. There have been studies of other plausible genes in GBS and CIDP and the role of these genes in GBS and CIDP and the data from these genetic studies is reviewed. Some of the genes that have been studied are immune related and some others have nervous system effects. The studies are limited by small numbers. Some of the genes show association with disease severity rather than disease susceptibility. The need for more detailed molecular studies of the role of HLA molecules and the need for modern genetic approaches to GBS and CIDP are explained.