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Impairment and disability in 20 CIDP patients according to disease activity status
Author(s) -
Panaite PetricaAdrian,
Renaud Susanne,
Kraftsik Rudolf,
Steck Andreas J.,
Kuntzer Thierry
Publication year - 2013
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/jns5.12038
Subject(s) - rasch model , polyradiculoneuropathy , cohort , physical therapy , medicine , grading scale , motor impairment , physical medicine and rehabilitation , disease , psychology , pediatrics , surgery , developmental psychology , guillain barre syndrome
Twenty patients with chronic inflammatory demyelinating polyradiculoneuropathy ( CIDP ) meeting the EFNS / PNS criteria were examined in order to assess differences/similarities between the various grading systems according to CIDP disease activity status ( CDAS ). A principal component ( PC ) analysis and the correlations between the following scores were performed: Neurological Symptom Score; MRC sum score; Neurological Impairment Score; Hammersmith Functional Motor Scale; Inflammatory Neuropathy Cause and Treatment ( INCAT ) Sensory Sum Score; Overall Disability Sum Score; INCAT Disability Score; Rasch‐built Overall Disability Scale. Our analysis outlined two main sets of scales, with high influence in the top two PCs . The first PC that best explained the variability within the cohort consisted of CDAS , general disability scores and motor scores; these parameters were also strongly correlated amongst each other. The second PC explained less the variability and consisted mainly of sensory scores and disease duration; these parameters did not correlate with the scores of the first PC or with the CDAS . Our findings suggest separating screening for motor and sensory deficits when evaluating CIDP patients, as only the motor scores correlate with CDAS .