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The Hippo pathway: Horizons for innovative treatments of peripheral nerve diseases
Author(s) -
Feltri M. Laura,
Weaver Michael R.,
Belin Sophie,
Poitelon Yannick
Publication year - 2021
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/jns.12431
Subject(s) - hippo signaling pathway , neuroscience , biology , peripheral nervous system , function (biology) , peripheral , nervous system , microbiology and biotechnology , signal transduction , central nervous system , medicine
Initially identified in Drosophila , the Hippo signaling pathway regulates how cells respond to their environment by controlling proliferation, migration and differentiation. Many recent studies have focused on characterizing Hippo pathway function and regulation in mammalian cells. Here, we present a brief overview of the major components of the Hippo pathway, as well as their regulation and function. We comprehensively review the studies that have contributed to our understanding of the Hippo pathway in the function of the peripheral nervous system and in peripheral nerve diseases. Finally, we discuss innovative approaches that aim to modulate Hippo pathway components in diseases of the peripheral nervous system.