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New novel mutations in Brazilian families with X‐linked Charcot‐Marie‐Tooth disease
Author(s) -
Gouvea Silmara P.,
Tomaselli Pedro J.,
Barretto Luiza S.,
Perina Keity C. B.,
Nyshyama Fulviana S.,
Nicolau Nilson,
Lourenço Charles M.,
Marques Wilson
Publication year - 2019
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/jns.12327
Subject(s) - tooth disease , sanger sequencing , subclinical infection , genetics , disease , genotype , coding region , mutation , gene , medicine , biology
Mutations in the GJB1 gene are the second most frequent cause of Charcot‐Marie‐Tooth disease (CMT), accounting for approximately 10% of CMT cases worldwide. We retrospectively analyzed detailed clinical and neurophysiological data on four Brazilian families carrying novel mutations of the GJB1 gene. Mutations were identified by bidirectional Sanger sequence analysis on the GJB1 coding region. We identified a total of 12 subjects from four different kindred. There was no male‐to‐male transmission, and their clinical pictures were within the expected spectrum for GJB1‐related neuropathy. Males were more severely affected than females. Five out of the eight females only had subclinical neuropathy. Nerve conduction velocities were in the intermediate range in the male patients and higher in the females affected. These mutations increase the genotypic variability associated with GJB1 .