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Markers for Guillain‐Barré syndrome with poor prognosis: a multi‐center study
Author(s) -
Yamagishi Yuko,
Suzuki Hidekazu,
Sonoo Masahiro,
Kuwabara Satoshi,
Yokota Takanori,
Nomura Kyoichi,
Chiba Atsuro,
Kaji Ryuji,
Kanda Takashi,
Kaida Kenichi,
Ikeda Shuichi,
Mutoh Tatsuro,
Yamasaki Ryo,
Takashima Hiroshi,
Matsui Makoto,
Nishiyama Kazutoshi,
Sobue Gen,
Kusunoki Susumu
Publication year - 2017
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/jns.12234
Subject(s) - medicine , guillain barre syndrome , erasmus+ , mechanical ventilation , single center , pediatrics , antibody , immunology , art , the renaissance , art history
Guillain‐Barré syndrome (GBS) is an acute monophasic neuropathy. Prognostic tools include the modified Erasmus GBS outcome score (mEGOS), Erasmus GBS respiratory insufficiency score (EGRIS), and the increase in serum IgG levels (ΔIgG) 2 weeks after intravenous immunoglobulin (IVIg) treatment. Given that proportions of GBS subtypes differ between Western countries and Japan, the usefulness of these tools in Japan or other countries remains unknown. We enrolled 177 Japanese patients with GBS from 15 university hospitals and retrospectively obtained mEGOS and EGRIS for all and ΔIgG status for 79 of them. High mEGOS scores on admission or on day 7 were significantly associated with poorer outcomes (unable to walk independently at 6 months). High EGRIS scores (≥5 points) were associated with an increased risk for mechanical ventilation. Patients with ΔIgG <1,108 mg/dl had significantly poorer outcomes. We suggest that mEGOS, EGRIS, and ΔIgG in GBS are clinically relevant in Japan.