Premium
Pain in chemotherapy‐induced peripheral neurotoxicity
Author(s) -
Marmiroli Paola,
Scuteri Arianna,
Cornblath David R.,
Cavaletti Guido
Publication year - 2017
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/jns.12226
Subject(s) - neurotoxicity , medicine , context (archaeology) , chemotherapy induced peripheral neuropathy , peripheral , limiting , clinical trial , intensive care medicine , toxicity , peripheral neuropathy , mechanical engineering , paleontology , endocrinology , engineering , biology , diabetes mellitus
Chemotherapy‐induced peripheral neurotoxicity ( CIPN ) is a potentially dose‐limiting side effect of the treatment of several cancers. CIPN is predominantly or exclusively sensory, and it is frequently associated with unpleasant symptoms, overall referred to as “pain.” However, given the markedly different clinical presentation and course of CIPN depending on the antineoplastic drug used, the broad term “pain” in the specific context of CIPN needs to be reconsidered and refined. In fact, a precise identification of the features of CIPN has relevant implication in the design of rational‐based clinical trials and in the selection of possible active drugs.