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Relationship between physical performance and quality of life in Charcot‐Marie‐Tooth disease: a pilot study
Author(s) -
RobertsClarke Daniel,
Fornusek Che,
Saigal Nidhi,
Halaki Mark,
Burns Joshua,
Nicholson Garth,
Fiatarone Singh Maria,
Hackett Daniel
Publication year - 2016
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/jns.12191
Subject(s) - tooth disease , disease , quality of life (healthcare) , medicine , gerontology , quality (philosophy) , psychology , physical medicine and rehabilitation , physical therapy , nursing , philosophy , pathology , epistemology
Charcot‐Marie‐Tooth (CMT) is a rare inherited peripheral neuropathy in which quality of life (QoL) is reduced compared with the general population. This paper investigates the relationship between QoL and physical performance in people with CMT with the aim of identifying avenues for future research into rehabilitation strategies. Cross‐sectional data was obtained from 10 participants (5 men, 5 women, age 46 ± 13 years, height 1.7 ± 0.1 m, body mass 77 ± 17 kg) with CMT (CMT1A n = 5; CMT‐X n = 3; unknown genetic origin n = 2). Participants were evaluated for QoL, falls efficacy (FES), balance, mobility, muscle strength, and power. Physical component score (PCS) of the Short Form‐36 (SF‐36) was significantly and directly related to higher leg press power (r = 0.75, p = 0.02). Better FES scores were significantly related to faster habitual gait speed (r = −0.70, p = 0.02), left hip abduction, and seated row strength (r = −0.68, p = 0.03; r = −0.73, p = 0.03, respectively). Future research should aim to substantiate these preliminary findings in a larger cohort and investigate whether interventions targeting muscle strength and power can improve QoL and mobility outcomes in people with CMT.