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Cytoalbuminologic dissociation in Asian patients with Guillain‐Barré and Miller Fisher syndromes
Author(s) -
Wong Anna Hiu Yi,
Umapathi Thirugnanam,
Nishimoto Yukihiro,
Wang Yu Zhong,
Chan Yee Cheun,
Yuki Nobuhiro
Publication year - 2015
Publication title -
journal of the peripheral nervous system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 67
eISSN - 1529-8027
pISSN - 1085-9489
DOI - 10.1111/jns.12104
Subject(s) - pleocytosis , lumbar puncture , guillain barre syndrome , medicine , csf pleocytosis , cerebrospinal fluid , lumbar , miller fisher syndrome , cohort , gastroenterology , dissociation (chemistry) , immunology , surgery , chemistry
Cerebrospinal fluid ( CSF ) protein level, cell count, and its relationship to the timing of lumbar puncture were collected from patients with Guillain‐Barré syndrome ( GBS ) and Miller Fisher syndrome ( MFS ) from various Asian centers. A total of 507 patients with GBS were studied. Overall, 56% had elevated CSF protein level. This was significantly lower than that reported in a recent Dutch study (56% vs 64%). Cytoalbuminologic dissociation was also lower in the Asian cohort (55% vs 64%), with a significantly higher proportion of patients with mild pleocytosis (26% vs 15%). A lower proportion of the 164 patients with MFS had elevated CSF protein level (38% vs 56%), mild pleocytosis (11% vs 26%), and cytoalbuminologic dissociation (41% vs 55%) compared to patients with GBS . In both conditions, cytoalbuminologic dissociation was linked to the timing of lumbar puncture. Cytoalbuminologic dissociation was only observed in half of the Asian patients with GBS and MFS , and it is strongly dependent on the timing of the lumbar puncture.