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Pre‐frontal‐insular‐cerebellar modifications correlate with disgust feeling blunting after subthalamic stimulation: A positron emission tomography study in P arkinson's disease
Author(s) -
Ory Sophie,
Le Jeune Florence,
Haegelen Claire,
Vicente Siobhan,
Philippot Pierre,
Dondaine Thibaut,
Jannin Pierre,
Drapier Sophie,
Drapier Dominique,
Sauleau Paul,
Vérin Marc,
Péron Julie
Publication year - 2017
Publication title -
journal of neuropsychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.85
H-Index - 37
eISSN - 1748-6653
pISSN - 1748-6645
DOI - 10.1111/jnp.12094
Subject(s) - psychology , disgust , orbitofrontal cortex , feeling , insula , precuneus , neuroimaging , neuroscience , positron emission tomography , internal capsule , deep brain stimulation , parkinson's disease , prefrontal cortex , white matter , functional magnetic resonance imaging , magnetic resonance imaging , cognition , disease , medicine , clinical psychology , anger , radiology , social psychology
Subthalamic nucleus ( STN ) deep brain stimulation ( DBS ) has recently advanced our understanding of the major role played by this basal ganglion in human emotion. Research indicates that STN DBS can induce modifications in all components of emotion, and neuroimaging studies have shown that the metabolic modifications correlated with these emotional disturbances following surgery are both task‐ and sensory input‐dependent. Nevertheless, to date, these modifications have not been confirmed for all emotional components, notably subjective emotional experience, or feelings . To identify the neural network underlying the modification of feelings following STN DBS , we assessed 16 patients with P arkinson's disease before and after surgery, using both subjective assessments of emotional experience and 18 [ F ]fluorodeoxyglucose positron emission tomography ( 18 FDG ‐ PET ). The patients viewed six film excerpts intended to elicit happy, angry, fearful, sad, disgusted, and neutral feelings, and they self‐rated the intensity of these feelings. After DBS , there was a significant reduction in the intensity of the disgust feeling. Correlations were observed between decreased disgust experience and cerebral glucose metabolism ( FDG uptake) in the bilateral pre‐frontal cortices (orbitofrontal, dorsolateral, and inferior frontal gyri), bilateral insula, and right cerebellum. We suggest that the STN contributes to the synchronization process underlying the emergence of feelings.