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68 Ga‐DOTATOC‐PET/MRI and 11 C‐5‐HTP‐PET/MRI are superior to 68 Ga‐DOTATOC‐PET/CT for neuroendocrine tumour imaging
Author(s) -
Jawlakh Hiba,
Velikyan Irina,
Welin Staffan,
Sundin Anders
Publication year - 2021
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/jne.12981
Subject(s) - nuclear medicine , medicine , magnetic resonance imaging , positron emission tomography , pet ct , pet imaging , radiology
The present study aimed to assess gadoxetate disodium contrast‐enhanced (CE) positron emission tomography (PET)/magnetic resonance imaging (MRI) with 68 Ga‐DOTATOC and 11 C‐5‐Hydroxy‐tryptophan ( 11 C‐5‐HTP) in comparison with iodine CE 68 Ga‐DOTATOC‐PET/computed tomography (CT) for neuroendocrine tumour imaging. Detection rate and reader's confidence were evaluated for each separate image volume: CE‐CT, CE‐MRI including diffusion‐weighted imaging, 68 Ga‐DOTATOC‐PET performed at PET/CT, 68 Ga‐DOTATOC‐PET performed at PET/MRI and 11 C‐5‐HTP‐PET, and for the three combined hybrid examinations 68 Ga‐DOTATOC‐PET/MRI, 11 C‐5‐HTP‐PET/MRI and 68 Ga‐DOTATOC‐PET/CT. In 11 patients, 255 lesions were depicted. 68 Ga‐DOTATOC‐PET performed at PET/MRI depicted 72.5%, 68 Ga‐DOTATOC‐PET performed at PET/CT depicted 62.7%, 11 C‐5‐HTP‐PET depicted 68.2% and CE‐CT depicted 53% of lesions. 68 Ga‐DOTATOC‐PET performed at PET/MRI ( P < 0.001) and PET/CT ( P = 0.02), 11 C‐5‐HTP‐PET ( P < 0.001) and MRI ( P < 0.001) were superior to CT. 68 Ga‐DOTATOC‐PET/MRI and 11 C‐5‐HTP‐PET/MRI detected 92.5% and 92% of lesions, respectively, and both outperformed 68 Ga‐DOTATOC‐PET/CT (65%) ( P < 0.001). For liver metastasis imaging, MRI alone was unsurpassed ( P < 0.01) and 68 Ga‐DOTATOC‐PET/MRI and 11 C‐5‐HTP‐PET/MRI outperformed 68 Ga‐DOTATOC‐PET/CT ( P < 0.001). For lymph node metastasis diagnosis, 68 Ga‐DOTATOC‐PET performed at PET/MRI and PET/CT and 11 C‐5‐HTP‐PET detected 94%, 94% and 94% of lesions, respectively, and outperformed MRI and CE‐CT alone ( P < 0.001). For bone metastasis imaging, 68 Ga‐DOTATOC‐PET performed at PET/MRI and PET/CT and 11 C‐5‐HTP‐PET performed equally well ( P = 0.05) and better than MRI. Reader's confidence was better for 68 Ga‐DOTATOC‐PET/MRI and 11 C‐5‐HTP‐PET/MRI than for 68 Ga‐DOTATOC‐PET/CT. The tumour maximum standardised uptake value and tumour‐to‐liver ratio were both approximately twice as high as for 68 Ga‐DOTATOC than for 11 C‐5‐HTP. 68 Ga‐DOTATOC‐PET/MRI and 11 C‐5‐HTP‐PET/MRI provided the highest detection rates and reader's confidence and were both superior to 68 Ga‐DOTATOC‐PET/CT, mainly because of the MRI component. The imaging contrast with 68 Ga‐DOTATOC was superior to that of 11 C‐5‐HTP.