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Insulin on the brain: The role of central insulin signalling in energy and glucose homeostasis
Author(s) -
Beddows Cait A.,
Dodd Garron T.
Publication year - 2021
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/jne.12947
Subject(s) - insulin , homeostasis , glucose homeostasis , endocrinology , energy homeostasis , medicine , insulin receptor , pathogenesis , parenchyma , energy metabolism , biology , insulin resistance , obesity , botany
Abstract Insulin signals to the brain where it coordinates multiple physiological processes underlying energy and glucose homeostasis. This review explores where and how insulin interacts within the brain parenchyma, how brain insulin signalling functions to coordinate energy and glucose homeostasis and how this contributes to the pathogenesis of metabolic disease.