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Endocrine cross‐talk between the gut microbiome and glial cells in development and disease
Author(s) -
Anbalagan Savani
Publication year - 2021
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/jne.12924
Subject(s) - microbiome , biology , gliogenesis , neuroglia , neuroscience , gut–brain axis , epigenetics , disease , central nervous system , immunology , microbiology and biotechnology , stem cell , genetics , pathology , medicine , progenitor cell , gene
Abstract Glial cells make up the major cellular component of the nervous system. Glial development is usually investigated through perturbations of host genetics, although non‐host‐derived signalling molecules can also regulate glial cells. Indeed, gut microbiome colonisation and the presence of microbiome‐derived factors in the blood coincide with glial cell development. Emerging data suggest that the gut microbiome can regulate gliogenesis, myelination and glial epigenetics. Neurodegenerative diseases are characterised by changes in the gut microbiome and glial dysfunction. This perspective discusses the ways in which microbiome‐derived molecules can engage in cross‐talk with glial cells during development and in dysfunctional glial diseases.