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Pre‐ and post‐synaptic modulation by GABA B receptors of rat neuroendocrine dopamine neurones
Author(s) -
Ammari Rachida,
Broberger Christian
Publication year - 2020
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/jne.12881
Subject(s) - gabab receptor , postsynaptic potential , endocrinology , autoreceptor , medicine , dopamine , prolactin , biology , neurotransmitter , receptor , agonist , neuroscience , chemistry , hormone , central nervous system
The secretion of prolactin from the pituitary is negatively controlled by tuberoinfundibular dopamine (TIDA) neurones. The electrical properties of TIDA cells have recently been identified as a modulatory target of neurotransmitters and hormones in the lactotrophic axis. The role of the GABA B receptor in this control has received little attention, yet is of particular interest because it may act as a TIDA neurone autoreceptor. Here, this issue was explored in a spontaneously active rat TIDA in vitro slice preparation using whole‐cell recordings. Application of the GABA B receptor agonist, baclofen, dose‐dependently slowed down or abolished the network oscillations typical of this preparation. Pharmacological manipulations identify the underlying mechanism as an outward current mediated by G‐protein‐coupled inwardly rectifying K + ‐like channels. In addition to this postsynaptic modulation, we describe a presynaptic modulation where GABA B receptors restrain the release of glutamate and GABA onto TIDA neurones. Our data identify both pre‐ and postsynaptic modulation of TIDA neurones by GABA B receptors that may play a role in the neuronal network control of pituitary prolactin secretion and lactation.