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Premium Regulatory peptides and systems biology: A new era of translational and reverse‐translational neuroendocrinology
Author(s)
Eiden Lee E.,
Gundlach Andrew L.,
Grinevich Valery,
Lee Mary R.,
Mecawi André S.,
Chen Duan,
Buijs Ruud M.,
Hernandez Vito S.,
Fajardo-Dolci Germán,
Zhang Limei
Publication year2020
Publication title
journal of neuroendocrinology
Resource typeJournals
PublisherWiley-Blackwell
Abstract Recently, there has been a resurgence in regulatory peptide science as a result of three converging trends. The first is the increasing population of the drug pipeline with peptide‐based therapeutics, mainly in, but not restricted to, incretin‐like molecules for treatment of metabolic disorders such as diabetes. The second is the development of genetic and optogenetic tools enabling new insights into how peptides actually function within brain and peripheral circuits to accomplish homeostatic and allostatic regulation. The third is the explosion in defined structures of the G‐protein coupled receptors to which most regulatory peptides bind and exert their actions. These trends have closely wedded basic systems biology to drug discovery and development, creating a “two‐way street” on which translational advances travel from basic research to the clinic, and, equally importantly, “reverse‐translational” information is gathered, about the molecular, cellular and circuit‐level mechanisms of action of regulatory peptides, comprising information required for the fine‐tuning of drug development through testing in animal models. This review focuses on a small group of ‘influential’ peptides, including oxytocin, vasopressin, pituitary adenylate cyclase‐activating polypeptide, ghrelin, relaxin‐3 and glucagon‐like peptide‐1, and how basic discoveries and their application to therapeutics have intertwined over the past decade.
Subject(s)bioinformatics , biology , computational biology , drug , drug development , drug discovery , endocrinology , environmental health , genetics , ghrelin , hormone , medicine , microbiology and biotechnology , neuroendocrinology , neuroscience , pharmacology , population , receptor , translational medicine , translational research
Language(s)English
SCImago Journal Rank1.062
H-Index116
eISSN1365-2826
pISSN0953-8194
DOI10.1111/jne.12844

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