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Thirty years of neuroendocrinology: Technological advances pave the way for molecular discovery
Author(s) -
Stubbs Felicity E.,
ConwayCampbell Becky L.,
Lightman Stafford L.
Publication year - 2019
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/jne.12653
Subject(s) - neuroendocrinology , epigenetics , epigenomics , biology , molecular genetics , neuroscience , pharmacogenetics , bioinformatics , computational biology , endocrinology , medicine , genetics , gene , hormone , dna methylation , gene expression , genotype
Since the 1950s, the systems level interactions between the hypothalamus, pituitary and end organs such as the adrenal, thyroid and gonads have been well known; however, it is only over the last three decades that advances in molecular biology and information technology have provided a tremendous expansion of knowledge at the molecular level. Neuroendocrinology has benefitted from developments in molecular genetics, epigenetics and epigenomics, and most recently optogenetics and pharmacogenetics. This has enabled a new understanding of gene regulation, transcription, translation and post‐translational regulation, which should help direct the development of drugs to treat neuroendocrine‐related diseases.