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Gonadotrophin‐inhibitory hormone and its mammalian orthologue RF amide‐related peptide‐3: Discovery and functional implications for reproduction and stress
Author(s) -
Kriegsfeld L. J.,
Jennings K. J.,
Bentley G. E.,
Tsutsui K.
Publication year - 2018
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/jne.12597
Subject(s) - biology , neuropeptide , hormone , endocrinology , medicine , inhibitory postsynaptic potential , reproduction , gonadotropin releasing hormone , receptor , genetics , luteinizing hormone
At the turn of the millennium, a neuropeptide with pronounced inhibitory actions on avian pituitary gonadotrophin secretion was identified and named gonadotrophin‐inhibitory hormone (Gn IH ). Across bird species, Gn IH acts at the level of the pituitary and the gonadotrophin‐releasing hormone (Gn RH ) neuronal system to inhibit reproduction. Subsequent to this initial discovery, orthologues of Gn IH have been identified and characterised across a broad range of species. In many vertebrates, the actions of Gn IH and its orthologues serve functional roles analogous to those seen in birds. In other cases, Gn IH and its orthologues exhibit more diverse actions dependent on sex, species, season and reproductive condition. The present review highlights the discovery and functional implications of Gn IH across species, focusing on research domains in which the significance of this neuropeptide has been explored most.