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Insulin action in the brain: Roles in energy and glucose homeostasis
Author(s) -
Dodd G. T.,
Tiganis T.
Publication year - 2017
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/jne.12513
Subject(s) - glucose homeostasis , energy homeostasis , insulin , endocrinology , medicine , homeostasis , type 2 diabetes , energy metabolism , diabetes mellitus , obesity , biology , carbohydrate metabolism , neuroscience , insulin resistance
A growing body of evidence from research in rodents and humans has identified insulin as an important neuoregulatory peptide in the brain, where it coordinates diverse aspects of energy balance and peripheral glucose homeostasis. This review discusses where and how insulin interacts within the brain and evaluates the physiological and pathophysiological consequences of central insulin signalling in metabolism, obesity and type 2 diabetes.