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Less is more: Caloric regulation of neurogenesis and adult brain function
Author(s) -
Morgan A. H.,
Andrews Z. B.,
Davies J. S.
Publication year - 2017
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/jne.12512
Subject(s) - calorie restriction , ghrelin , caloric theory , neurogenesis , low calorie diet , endocrinology , medicine , calorie , caloric intake , neuroscience , hormone , ageing , intermittent fasting , biology , obesity , weight loss
Calorie intake is essential for regulating normal physiological processes and is fundamental to maintaining life. Indeed, both extremes of calorie intake result in increased morbidity and mortality. In this review, we discuss the effect of calorie intake on adult brain function, with an emphasis on the beneficial effects of mild calorie restriction. Recent findings relating to the regenerative and protective effects of the gastrointestinal hormone, ghrelin, suggest that it may underlie the beneficial effects of calorie restriction. We discuss the putative cellular mechanisms underlying the action of ghrelin and their possible role in supporting healthy brain ageing.