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NAD + : A key metabolic regulator with great therapeutic potential
Author(s) -
Sultani G.,
Samsudeen A. F.,
Osborne B.,
Turner N.
Publication year - 2017
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/jne.12508
Subject(s) - nad+ kinase , nicotinamide adenine dinucleotide , regulator , transcription factor , catabolism , biochemistry , biology , metabolism , nicotinamide phosphoribosyltransferase , microbiology and biotechnology , cofactor , chemistry , enzyme , gene
Nicotinamide adenine dinucleotide ( NAD + ) is a ubiquitous metabolite that serves an essential role in the catabolism of nutrients. Recently, there has been a surge of interest in NAD + biology, with the recognition that NAD + influences many biological processes beyond metabolism, including transcription, signalling and cell survival. There are a multitude of pathways involved in the synthesis and breakdown of NAD + , and alterations in NAD + homeostasis have emerged as a common feature of a range of disease states. Here, we provide an overview of NAD + metabolism and summarise progress on the development of NAD + ‐related therapeutics.