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SARS‐CoV ‐2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytes
Author(s) -
Oliveira Lilian Gomes,
Souza Angelo Yan,
Yamamoto Pedro,
Carregari Victor Corasolla,
Crunfli Fernanda,
ReisdeOliveira Guilherme,
Costa Lícia,
Vendramini Pedro Henrique,
Duque Érica Almeida,
Santos Nilton Barreto,
Firmino Egidi Mayara,
Paiva Isadora Marques,
Almeida Glaucia Maria,
Sebollela Adriano,
Polonio Carolina Manganeli,
Zanluqui Nagela Ghabdan,
Oliveira Marília Garcia,
Silva Patrick,
Davanzo Gustavo Gastão,
Ayupe Marina Caçador,
Salgado Caio Loureiro,
Souza Filho Antônio Francisco,
Araújo Marcelo Valdemir,
SilvaPereira Taiana Tainá,
Almeida Campos Angélica Cristine,
Góes Luiz Gustavo Bentim,
Passos Cunha Marielton,
Caldini Elia Garcia,
D'Império Lima Maria Regina,
Fonseca Denise Morais,
Sá Guimarães Ana Márcia,
Minoprio Paola Camargo,
Munhoz Carolina Demarchi,
Mori Cláudia Madalena Cabrera,
MoraesVieira Pedro Manoel,
Cunha Thiago Mattar,
MartinsdeSouza Daniel,
Peron Jean Pierre Schatzmann
Publication year - 2022
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.15679
Subject(s) - glutamine , glutaminolysis , glycolysis , biology , astrogliosis , olfactory bulb , astrocyte , hippocampus , neurotransmission , metabolism , neuroscience , central nervous system , endocrinology , biochemistry , receptor , amino acid
COVID‐19 causes more than million deaths worldwide. Although much is understood about the immunopathogenesis of the lung disease, a lot remains to be known on the neurological impact of COVID‐19. Here, we evaluated immunometabolic changes using astrocytes in vitro and dissected brain areas of SARS‐CoV‐2 infected Syrian hamsters. We show that SARS‐CoV‐2 alters proteins of carbon metabolism, glycolysis, and synaptic transmission, many of which are altered in neurological diseases. Real‐time respirometry evidenced hyperactivation of glycolysis, further confirmed by metabolomics, with intense consumption of glucose, pyruvate, glutamine, and alpha ketoglutarate. Consistent with glutamine reduction, the blockade of glutaminolysis impaired viral replication and inflammatory response in vitro. SARS‐CoV‐2 was detected in vivo in hippocampus, cortex, and olfactory bulb of intranasally infected animals. Our data evidence an imbalance in important metabolic molecules and neurotransmitters in infected astrocytes. We suggest this may correlate with the neurological impairment observed during COVID‐19, as memory loss, confusion, and cognitive impairment.