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Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease
Author(s) -
Jakaria Md.,
Belaidi Abdel Ali,
Bush Ashley I.,
Ayton Scott
Publication year - 2021
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.15519
Subject(s) - neurodegeneration , mechanism (biology) , disease , neuroscience , dementia , alzheimer's disease , pathogenesis , amyloid (mycology) , programmed cell death , pathophysiology , medicine , biology , pathology , apoptosis , philosophy , genetics , epistemology
Alzheimer's disease (AD) is the most prevalent form of dementia, with complex pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary tangles define the pathology of the disease, the mechanism of neurodegeneration is uncertain. Ferroptosis is an iron‐mediated programmed cell death mechanism characterised by phospholipid peroxidation that has been observed in clinical AD samples. This review will outline the growing molecular and clinical evidence implicating ferroptosis in the pathogenesis of AD, with implications for disease‐modifying therapies.