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Issue Information
Publication year - 2022
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.15412
Subject(s) - acetylation , myelin , sciatic nerve , regeneration (biology) , microbiology and biotechnology , cytoskeleton , mitochondrion , mechanism (biology) , biology , chemistry , neuroscience , biochemistry , anatomy , central nervous system , physics , cell , gene , quantum mechanics
Front cover Accumulating evidence suggests the involvement of protein acetylation in modulating the biology of Schwann cells (SCs) and regeneration of the peripheral nervous system (PNS). However, the cellular and molecular mechanisms underlying these processes remain partially understood. Here, we provided a comprehensive sciatic nerve (SN) acetylome of adult C57BL/6 mice for the first time, comprising 483 acetylated proteins and 1,442 acetylation modification sites. Bioinformatics analysis suggested that these acetylated SN proteins were mainly located in the myelin sheath, mitochondrial inner membrane, and cytoskeleton. These data will extend our understanding and promote further study on the role and mechanism of protein acetylation in SC maintenance and regeneration of PNS. Image content The image illustrated the co‐localization of acetylated alpha‐tubulin (K40) (red) with S100‐positive SCs (green).Read the full article ‘ The acetylome of adult mouse sciatic nerve ’ by M. Shen, Z. Chen, M. Ming, Z. Cheng, J. Sun, Q. Liang, T. Shang, Q. Zhang, S. Zhou, Y. Ji and F. Ding (J. Neurochem. 2022, vol. 162 (3), pp. 262–275) on doi: 10.1111/jnc.15648