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Ferroptosis: An emerging therapeutic target in stroke
Author(s) -
Liu Yibo,
Fang Yuanjian,
Zhang Zeyu,
Luo Yujie,
Zhang Anke,
Lenahan Cameron,
Chen Sheng
Publication year - 2022
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.15351
Subject(s) - stroke (engine) , pathological , mechanism (biology) , disease , autophagy , programmed cell death , medicine , apoptosis , cancer , neuroscience , cause of death , bioinformatics , pathology , biology , genetics , mechanical engineering , philosophy , epistemology , engineering
Stroke is a disastrous neurological disease with high morbidity and mortality. The mechanism of the pathological process is extremely complicated and unclear. Although many basic studies have confirmed molecular mechanism of brain injury after stroke, these studies have not yet translated into treatment and clinical application. Ferroptosis is a form of cell death that is distinct from necrosis, apoptosis, and autophagy morphologically and biochemically and is characterized by iron‐dependent accumulation of lipid peroxides. Despite ferroptosis being first identified in cancer cells, it was recently revealed to also be a significant factor in the pathological process of stroke. A better understanding of ferroptosis in stroke may provide us with better therapeutic targets to treat this devastating disease. Here, we systematically summarized the current mechanism of ferroptosis and reviewed the current studies regarding the relationship between ferroptosis and stroke.