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Preface to the Special Issue “Presynaptic Dysfunction and Disease”
Author(s) -
Smillie Karen J.,
Cousin Michael A.,
Gordon Sarah L.
Publication year - 2021
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.15319
Subject(s) - neuroscience , synapse , neurotransmitter , mediator , neurotransmitter systems , disease , neurotransmission , neurotransmitter agents , psychology , biology , cognitive science , medicine , central nervous system , dopamine , endocrinology , receptor , biochemistry
The synapse is formed between a presynapse (which releases neurotransmitter) and the postsynapse (which transduces this chemical signal). Over the past decade, presynaptic dysfunction has emerged as a key mediator of a series of neurodevelopmental and neurodegenerative disorders. This special issue will highlight some of the important presynaptic molecules and mechanisms that are disrupted in these conditions and reveal potential routes for therapy.