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Exosomes in Parkinson disease
Author(s) -
Pinnell Jennifer R.,
Cui Mei,
Tieu Kim
Publication year - 2021
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.15288
Subject(s) - microvesicles , parkinson's disease , disease , microrna , extracellular vesicles , neuroscience , pathological , exosome , biology , medicine , pathology , microbiology and biotechnology , gene , genetics
Parkinson disease (PD) is a prevalent neurodegenerative disease, in which the formation of misfolded and aggregated α‐synuclein is a key neuropathological hallmark. Recent studies reveal that extracellular vesicles such as exosomes present a potential mechanism for propagation of pathological α‐synuclein throughout the brain. The ability of exosomes to transport proteins and genetic material between cells, including mRNA and microRNAs which have been implicated in PD pathology, provides critical insights as to how exosomes may contribute to pathological progression in PD. Advances have also been made in the investigation of exosomes as potential tools for the modulation of Parkinson's pathology; their detection extracellularly may facilitate their use as biomarkers, while their small size could be utilised as vectors for the delivery of therapeutics. The aim of this review was to highlight our current knowledge of the role of exosomes in PD and potential clinical application.