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Neuron‐intrinsic origin of hyperexcitability during early pathogenesis of Alzheimer’s disease
Author(s) -
LeeLiu Dasfne,
GonzalezBillault Christian
Publication year - 2021
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.15248
Subject(s) - neuroscience , neurochemistry , pathogenesis , disease , hippocampal formation , hyperactivation , neurology , alzheimer's disease , biology , medicine , pathology
In Alzheimer's disease (AD), hippocampal hyperactivation is already present at early stages of the disorder, in some cases, even when the individual is still asymptomatic. Neuronal hyperexcitability has been described to occur before the deposition of amyloid beta plaques in mouse models of AD and has been attributed to an imbalance between excitatory and inhibitory activity. In this Editorial Highlight, we discuss the article by Sosulina et al., published in this issue of the Journal of Neurochemistry, which offers novel insights into the possible origins of this neuronal excitability observed during the early pathogenesis of AD.