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Iron promotes the clearance of α‐synuclein
Author(s) -
Tuo QingZhang,
Lei Peng
Publication year - 2020
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.15130
Subject(s) - iron homeostasis , autophagy , parkinson's disease , regulator , chemistry , homeostasis , alpha synuclein , microbiology and biotechnology , metabolism , biology , biochemistry , medicine , disease , apoptosis , gene
Both elevated iron and α‐synuclein (α‐syn) aggregates are neuropathological hallmarks of Parkinson's disease (PD). It has been previously shown that iron promotes α‐synuclein aggregation, and α‐synuclein dysfunction impairs iron metabolism. In their latest work, Kim et al . have shown that the H63D variant of the homeostatic iron regulator ( HFE ) facilitates α‐syn degradation via REDD1‐mediated autophagy. Mice with the H63D variant of HFE were protected against α‐syn toxicity. These results may shed light on recent clinical studies of PD using iron chelation therapy.