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Issue Information
Publication year - 2021
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.15081
Subject(s) - sonic hedgehog , neuroinflammation , wnt signaling pathway , neuroscience , hedgehog , blood–brain barrier , biology , central nervous system , autism spectrum disorder , hedgehog signaling pathway , autism , medicine , microbiology and biotechnology , signal transduction , inflammation , immunology , psychiatry
Front cover: Autism Spectrum Disorder (ASD) is a neurodevelopmental disease originating from combined genetic and environmental factors. Post‐mortem human studies and some animal ASD models have shown brain neuroinflammation, oxidative stress and changes in blood brain barrier (BBB) integrity. The balance between Wnt‐β‐catenin and Shh pathways controls angiogenesis, barriergenesis, neurodevelopment, central nervous system (CNS) morphogenesis and neuronal guidance. These interactions are critical to maintain BBB function in the mature CNS to prevent influx of pathogens and inflammatory cells. Dysregulation of the Sonic Hedgehog/Wingless‐related (Shh‐Wnt) pathway mediates neuroinflammation and endothelial injury and may thus lead to Autism Spectrum Disorder (ASD)‐characteristic symptoms. In this Review article we explore the role of the Sonic Hedgehog/Wingless‐related integration site (Shh/Wnt) pathways in neurodevelopment, neuroinflammation, andBBB development.Read the full article ‘Potential crosstalk between sonic hedgehog‐WNT signaling and neurovascular molecules: Implications for blood–brain barrier integrity in autism spectrum disorder ’ by E. Gozal, R. Jagadapillai, J. Cai and G. N. Barnes (J. Neurochem. 2021, vol. 159 (1), pp. 15–28) on doi: 10.1111/jnc.15460