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Issue Information
Publication year - 2021
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.15073
Subject(s) - porphyromonas gingivalis , rage (emotion) , glycation , receptor , downregulation and upregulation , medicine , immunology , chemistry , pathology , biology , neuroscience , periodontitis , biochemistry , gene
Front cover: The expression of RAGE (receptor of advanced glycation end products) was increased on cerebral endothelial cells of mice after systemic infection of P. gingivalis ( Porphyromonas gingivalis ), a key pathogen of periodontal disease. The upregulated RAGE expressions on cerebral endothelial cells may involve in transporting peripheral Aβ into brain because RAGE is known as a receptor for peripheral Aβ influx. Image Content: Fluorescent image of brain slice stained with RAGE (green), CD31 (red) and Hoechst (blue) in mice after systemic P. gingivalis infection.Read the full article ‘Receptor for advanced glycation end products up‐regulation in cerebral endothelial cells mediates cerebrovascular‐related amyloid β accumulation after Porphyromonas gingivalis infection’ F. Zeng, Y. Liu, W. Huang, H. Qing, T. Kadowaki, H. Kashiwazaki, J. Ni and Z. Wu ( J. Neurochem. 2021, vol. 158 (3), pp. 724–736) on doi: 10.1111/jnc.15096