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Front cover: The abnormalities of Glucocorticoid Receptor (GR) stress signaling pathway involved in dysfunction of mitochondria and stress‐mediated psychiatric disorders. Bcl‐2 associated athanogene (Bag‐1) is a target of mood stabilizers, which can regulating the function of GR. GR translocation into mitochondria to regulate the mitochondrial function and further affect the neural plasticity and adaptation. However, the process of GR translocation into mitochondria is unknown. We found that acute corticosterone (CORT) treatment enhanced Bag‐1/GR complex formation and GR mitochondrial translocation. By contrast, chronic CORT reduced Bag‐1/GR complex and mitochondrial GR levels, while Bag‐1 overexpression rescued these reductions and the depression‐like behaviors induced by chronic CORT. Our findings suggested that Bag‐1 is critical for GR trafficking to mitochondria and regulates affective resilience in response to CORT stimulation. Image Content: An immunofluorescent confocal micrograph showing the co‐expressing Bag‐1 (red) and GR (green) protein in cultured rat primary cortical neuron after CORT treatment. Bag‐1 protein were stained with anti‐Bag‐1 and Alexa‐Fluor 594 antibody; GR protein were stained with anti‐GR and Alexa‐Fluor 488 antibody; Cell nuclei was stained with DAPI (blue).Read the full article   ‘Bag‐1 mediates glucocorticoid receptor trafficking to mitochondria after corticosterone stimulation: Potential role in regulating affective resilience ’ by S. Luo, Y. Hou, Y. Zhang, L. Feng, R. G. Hunter, P. Yuan, Y. Jia, H. Li, G. Wang, H. K. Manji, B. S. McEwen, C. Xiao, H. Bao and J. Du ( J. Neurochem . 2021, vol. 158 (2), pp. 358–372) on doi: 10.1111/jnc.15211