Issue Cover (January 2021)

Front cover: Insulin receptor molecules are present on the soma and dendrites of hippocampal excitatory neurons in much higher quantities than on glia. In live neurons, insulin receptor molecules associate preferentially with inhibitory synapses and also with lipid nanodomains on dendritic shafts. Their mobility is reduced by low concentrations of TNFα, suggesting a new mechanism of action of this inflammatory cytokine. Image content : Insulin receptor mRNA detected with a probe against a constant exon (red dots) was localized to the somatodendritic compartment of hippocampal neurons (cyan) with, at most, a minor contribution from astrocytes (green).Read the full article   ‘Spatial dynamics of the insulin receptor in living neurons’ by M. Gralle, S. Labrecque, C. Salesse, P. De Koninck, ( J. Neurochem. 2021, vol. 156 (1), pp. 88–105) on doi: 10.1111/jnc.14950