Premium
Role of sphingolipid metabolism in neurodegeneration
Author(s) -
Alaamery Manal,
Albesher Nour,
Aljawini Nora,
Alsuwailm Moneera,
Massadeh Salam,
Wheeler Michael A.,
Chao ChunCheih,
Quintana Francisco J.
Publication year - 2021
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.15044
Subject(s) - neurodegeneration , sphingolipid , context (archaeology) , biology , neuroscience , microglia , central nervous system , alzheimer's disease , multiple sclerosis , nervous system , sphingosine 1 phosphate , sphingosine , disease , medicine , inflammation , immunology , microbiology and biotechnology , pathology , biochemistry , receptor , paleontology
Sphingolipids are a class of lipids highly enriched in the central nervous system (CNS), which shows great diversity and complexity, and has been implicated in CNS development and function. Alterations in sphingolipid metabolism have been described in multiple diseases, including those affecting the central nervous system (CNS). In this review, we discuss the role of sphingolipid metabolism in neurodegeneration, evaluating its direct roles in neuron development and health, and also in the induction of neurotoxic activities in CNS‐resident astrocytes and microglia in the context of neurologic diseases such as multiple sclerosis and Alzheimer's disease. Finally, we focus on the metabolism of gangliosides and sphingosine‐1‐phosphate, its contribution to the pathogenesis of neurologic diseases, and its potential as a candidate target for the therapeutic modulation of neurodegeneration.