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Friend or enemy? Review of 17β‐HSD10 and its role in human health or disease
Author(s) -
Vinklarova Lucie,
Schmidt Monika,
Benek Ondrej,
Kuca Kamil,
GunnMoore Frank,
Musilek Kamil
Publication year - 2020
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.15027
Subject(s) - disease , druggability , neuroscience , biology , hormone , enzyme , mitochondrion , bioinformatics , human health , medicine , microbiology and biotechnology , biochemistry , gene , environmental health
17β‐hydroxysteroid dehydrogenase (17β‐HSD10) is a multifunctional human enzyme with important roles both as a structural component and also as a catalyst of many metabolic pathways. This mitochondrial enzyme has important functions in the metabolism, development and aging of the neural system, where it is involved in the homeostasis of neurosteroids, especially in regard to estradiol, changes in which make it an essential part of neurodegenerative pathology. These roles therefore, indicate that 17β‐HSD10 may be a possible druggable target for neurodegenerative diseases including Alzheimer's disease (AD), and in hormone‐dependent cancer. The objective of this review was to provide a summary about physiological functions and pathological roles of 17β‐HSD10 and the modulators of its activity.