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Issue Cover (September 2020)
Publication year - 2020
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14761
Subject(s) - neural stem cell , citation , embryonic stem cell , progenitor cell , biology , cover (algebra) , stem cell , microbiology and biotechnology , computer science , biochemistry , library science , gene , mechanical engineering , engineering
Front cover: Short‐chain fatty acids (SCFAs) in the human body are produced mainly by anaerobic bacteria in the gut from their fermentation of dietary fibers. SCFAs have been reported to be key mediators in the communication between the gut and the brain. Multiple effects of the SCFAs on the nervous system have been shown, including regulation of microglial maturation and activation and of embryonic stem cell differentiation into neural cells. However, the effect of SCFAs on early human neural cells is unknown. Results show that SCFAs at physiological levels increased the proliferation of human neural progenitor cells, generated from a human embryonic stem cell line (HS980). This finding proposes that SCFAs can regulate early human neural system development, which might be relevant for a putative ‘maternal gut‐fetal brain‐axis’. Image content : Immunofluorescence staining image of human neural progenitor cells with Nestin (red), ZO‐1(green) and DAPI (blue), showing neural rosettes, tight junctions and nuclei.Read the full article ‘Enteric short‐chain fatty acids promote proliferation of human neural progenitor cells’ by L. L. Yang, V. Millischer, S. Rodin, D. F. MacFabe, J. C. Villaescusa, C. Lavebratt, ( J. Neurochem. 2020, vol. 154 (6), pp. 635–646) on doi: 10.1111/jnc.14928