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Issue Cover (September 2020)
Publication year - 2020
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14759
Subject(s) - nfat , ototoxicity , cover (algebra) , medicine , hair cell , cancer research , audiology , cochlea , calcineurin , transplantation , mechanical engineering , chemotherapy , cisplatin , engineering
Front cover: Auditory hair cell degeneration underlies hearing loss, and finding effective treatment has been a holy grail quest of hearing research. So far, a combination of antioxidants and other protective substances have proven successful to a limited extent. Our findings show that the combination of nuclear factor of activated T‐cells (NFAT) inhibitor and N‐acetylcysteine provides full protection from gentamicin damage in hair cells. The main advantage is that hair cell protection can be achieved using lower concentrations of eachcomponent, and thus decreasing their potential side effects. This approach could be beneficial as treatment not just in aminoglycoside‐induced ototoxicity, but in all cases of ROS‐induced cochlear damage, with noise‐induced hearing loss being one of them. Image content: Representative image of green phalloidin‐stained auditory hair cells of the cultured organ of Corti.Read the full article ‘Combination of antioxidants and NFAT (nuclear factor of activated T cells) inhibitor protects auditory hair cells from ototoxic insult’ by M. Sekulic‐Jablanovic, K. Voronkova, D. Bodmer, V. Petkovic, ( J. Neurochem . 2020, vol. 154 (5), pp. 519–529) on doi: 10.1111/jnc.14921