Issue Cover (July 2020)

Front cover: Cerebral ischemia results in the loss of hippocampal pyramidal neurons and induces cognitive dysfunction. Cerebral ischemia itself can induce endogenous neurogenesis, but it is generally far from enough, and only a little percentage of NSCs can successfully differentiate into new neurons. So, promoting endogenous neurogenesis will be a promising treatment for the ischemic brain damage. In this study, we demonstrated that LXRs activation can ameliorate long‐term cognitive dysfunction caused by cerebral ischemia by increasing neurogenesis, which possibly through the Wnt/β‐catenin signaling pathway activation. Our findings suggest that LXRs activation may have potential therapeutic effects on clinical treatment of cerebral ischemia. Image content: Confocal microscopy image of the hippocampal DG region immunolabeled for NeuN (green immunofluorescence staining) and BrdU (red immunofluorescence staining). Nuclei are shown in blue (Dapi signal). The BrdU+ / NeuN+ double‐labeled cells represent neural stem cells differentiate into neurons.Read the full article   ‘Activation of liver X receptor promotes hippocampal neurogenesis and improves long‐term cognitive function recovery in acute cerebral ischemia‐reperfusion mice’ by L. Chen, D. Song, B. Chen, X. Yang, O. Cheng, ( J. Neurochem . 2020, vol. 154 (2), pp. 205–217) on doi: 10.1111/jnc.14890