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Issue Cover (June 2020)
Publication year - 2020
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14747
Subject(s) - glutamatergic , neuroscience , ampa receptor , diaphragm (acoustics) , motor neuron , diaphragm muscle , glutamate receptor , biology , psychology , receptor , medicine , anatomy , spinal cord , physics , acoustics , loudspeaker , respiratory system
Front cover: Multiplex fluorescence in situ hybridization (RNAscope) was used in retrogradely‐labeled phrenic motor neurons to examine differences in the expression of excitatory glutamatergic (AMPA and NMDA) receptors across motor neurons of varying size. Converging evidence supports diaphragm motor units being recruited according to the size principle (i.e., phrenic motor neurons with smaller surface area recruited first). Rana et al. found size‐dependent differences in receptor mRNA density across phrenic motor neurons which may strengthen orderly recruitment of diaphragm motor units. Orderly recruitment of motor units permits generation of graded levels of force necessary for a range of motor behaviors. Image content: Representative maximum intensity projection image shows a cluster of phrenic motor neurons that were identified by retrograde labelling using intrapleural Alexa 488‐conjugated cholera toxin B in rat spinal cord. Magenta represents cholera toxin‐based fluorescence in motor neurons and blue, nuclear stain.Read the full article ‘Heterogeneous glutamatergic receptor mRNA expression across phrenic motor neurons in rats’ by S. Rana, G. C. Sieck, C. B. Mantilla, ( J. Neurochem. 2020, vol. 153 (5), pp. 586–598) on doi: 10.1111/jnc.14881