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Issue Cover (May 2020)
Publication year - 2020
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14743
Subject(s) - retinopathy of prematurity , diabetic retinopathy , retinal , aflibercept , retina , retinopathy , cover (algebra) , medicine , ophthalmology , computer science , neuroscience , psychology , surgery , biology , endocrinology , mechanical engineering , engineering , pregnancy , genetics , bevacizumab , chemotherapy , diabetes mellitus , gestational age
Front cover: Ocular microvasculopathies compromise vision in diseases as retinopathy of prematurity and proliferative diabetic retinopathy. Using the oxygen induced retinopathy mouse model, we investigated the effects of aflibercept in modulating the aberrant retinal microvascular response to ischemia. Image content: In this image, a magnified view of a flat‐mounted retina from a 17 day old mouse subjected to the oxygen‐induced retinopathy protocol and subsequently treated with aflibercept is shown. FITC‐labeled dextran (150 kDa) was injected intra‐peritoneally to animals 2 hours prior to sacrifice and was detected in the retinal microvasculature residing primarily within the vascular lumen (green). By contrast, immunolabeling of the tissue with an anti‐human IgG antibody (magenta) and visualization of cell nuclei with DAPI (white) revealed that Aflibercept is also detected in blood vessel walls, suggesting it can be transported across retinal endothelial cells under ischemic conditions. Albeit slow in nature, this controlled transport might be central to achieving the functional benefits in vision we report in our study.Read the full article ‘VEGF‐Trap is a potent modulator of vasoregenerative responses and protects dopaminergic amacrine network integrity in degenerative ischemic neovascular retinopathy’ by J. E. Rojo Arias, M. Economopoulou, D. A. Juárez López, A, Kurzbach, K. H. Au Yeung, V. Englmaier, M. Merdausl, M. Schaarschmidt, M. Ader, H. Morawietz, R. H. W. Funk, J. Jászai, ( J. Neurochem. 2020, vol. 153 (3), pp. 390–412) on doi: 10.1111/jnc.14875