Issue Cover (March 2020)

Front cover: Type‐2 receptors for angiotensin II had been implicated in chronic pain. We examined its role in inflammatory pain and demonstrated that its expression changed in different neuronal subpopulations of the dorsal root ganglia at different times after cutaneous inflammation. Furthermore, this receptor works co‐operatively with the type‐1 receptor for angiotensin II via regulation of the neuritogenic activity of Angiotensin II on non‐peptidergic isolectin B4 binding and peptidergic trkA‐expressing dorsal root ganglion neurons. These findings have important implications for the clinical use of angiotensin‐II receptor blockers in the treatment of pain. Image content: Triple immunofluorescence confocal micrograph showing L5 adult dorsal root ganglion neurons expressing the type 2 receptor for angiotensin II (in red), binding of isolectin B4 (in green) and expression of trkA (in blue). Scale bar represents 30 μm.Read the full preface   ‘Cutaneous inflammation differentially regulates the expression and function of Angiotensin‐II types 1 and 2 receptors in rat primary sensory neurons’ by S. G. Benitez, A. M Seltzer, D. N Messina, M. B Foscolo, S. I. Patterson, C. G. Acosta (J. Neurochem. 2020, vol. 152 (6), pp. 675–696) on doi: 10.1111/jnc.14848