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Current status and potential role of circular RNAs in neurological disorders
Author(s) -
Lu Shanshan,
Yang Xue,
Wang Chudong,
Chen Siqi,
Lu Shuang,
Yan Weitao,
Xiong Kun,
Liu Fengxia,
Yan Jie
Publication year - 2019
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14724
Subject(s) - circular rna , neuroscience , disease , biology , neurotoxicity , bioinformatics , medicine , microrna , pathology , genetics , gene , toxicity
Given the importance of non‐coding RNAs in modulating normal brain functions and their implications in the treatment of neurological disorders, non‐coding RNA‐based diagnostic and therapeutic strategies have shown great clinical potential. Circular RNAs (circRNAs) have emerged as potentially important players in this field. Recent studies have indicated that circRNAs might play vital roles in Alzheimer’s disease, Parkinson’s disease, ischemic brain injury, and neurotoxicity. However, the mechanisms of action of circRNAs have not been fully characterized. We aimed to review recent advances in circRNA research in the brain to provide new insights on the roles of circRNAs in neurological disorders.